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PAPP‐A: a promising therapeutic target for healthy longevity

Pregnancy‐associated plasma protein‐A (PAPP‐A) is a proteolytic enzyme that was discovered to increase local insulin‐like growth factor (IGF) availability for receptor activation through cleavage of inhibitory IGF binding proteins (IGFBPs). Reduced IGF signaling has been associated with increased li...

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Bibliografiske detaljer
Udgivet i:Aging Cell
Main Authors: Conover, Cheryl A., Oxvig, Claus
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5334524/
https://ncbi.nlm.nih.gov/pubmed/28035757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12564
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