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Transgene Expression and Host Cell Responses to Replication-Defective, Single-Cycle, and Replication-Competent Adenovirus Vectors

Most adenovirus (Ad) vectors are E1 gene deleted replication defective (RD-Ad) vectors that deliver one transgene to the cell and all expression is based on that one gene. In contrast, E1-intact replication-competent Ad (RC-Ad) vectors replicate their DNA and their transgenes up to 10,000-fold, ampl...

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Bibliografiske detaljer
Udgivet i:Genes (Basel)
Main Authors: Crosby, Catherine M., Barry, Michael A.
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5333068/
https://ncbi.nlm.nih.gov/pubmed/28218713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/genes8020079
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