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IIIa Deleted Adenovirus as a Single-Cycle Genome Replicating Vector
Replication competent adenovirus (RC-Ad) vectors mediate robust transgene expression by virtue of amplifying transgenes by replication, but also put patients at a risk of frank adenovirus infection. In contrast, E1-deleted replication defective Ad (RD-Ad) vectors are safer, but produce substantially...
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| Main Authors: | , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2014
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4125442/ https://ncbi.nlm.nih.gov/pubmed/24996029 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2014.05.030 |
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