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IIIa Deleted Adenovirus as a Single-Cycle Genome Replicating Vector

Replication competent adenovirus (RC-Ad) vectors mediate robust transgene expression by virtue of amplifying transgenes by replication, but also put patients at a risk of frank adenovirus infection. In contrast, E1-deleted replication defective Ad (RD-Ad) vectors are safer, but produce substantially...

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Main Authors: Crosby, Catherine M., Barry, Michael A.
格式: Artigo
語言:Inglês
出版: 2014
主題:
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4125442/
https://ncbi.nlm.nih.gov/pubmed/24996029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2014.05.030
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