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Amplified and Persistent Immune Responses Generated by Single-Cycle Replicating Adenovirus Vaccines

Replication-competent adenoviral (RC-Ad) vectors generate exceptionally strong gene-based vaccine responses by amplifying the antigen transgenes they carry. While they are potent, they also risk causing adenovirus infections. More common replication-defective Ad (RD-Ad) vectors with deletions of E1...

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Dettagli Bibliografici
Pubblicato in:J Virol
Autori principali: Crosby, Catherine M., Nehete, Pramod, Sastry, K. Jagannadha, Barry, Michael A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4301142/
https://ncbi.nlm.nih.gov/pubmed/25355873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02184-14
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