Genome-wide barcoded transposon screen for cancer drug sensitivity in haploid mouse embryonic stem cells

We describe a screen for cellular response to drugs that makes use of haploid embryonic stem cells. We generated ten libraries of mutants with piggyBac gene trap transposon integrations, totalling approximately 100,000 mutant clones. Random barcode sequences were inserted into the transposon vector...

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Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:Sci Data
Κύριοι συγγραφείς: Pettitt, Stephen J., Krastev, Dragomir B., Pemberton, Helen N., Fontebasso, Yari, Frankum, Jessica, Rehman, Farah L., Brough, Rachel, Song, Feifei, Bajrami, Ilirjana, Rafiq, Rumana, Wallberg, Fredrik, Kozarewa, Iwanka, Fenwick, Kerry, Armisen-Garrido, Javier, Swain, Amanda, Gulati, Aditi, Campbell, James, Ashworth, Alan, Lord, Christopher J.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Nature Publishing Group 2017
Θέματα:
Data Descriptor
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5332012/
https://ncbi.nlm.nih.gov/pubmed/28248920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sdata.2017.20
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