Genome-wide barcoded transposon screen for cancer drug sensitivity in haploid mouse embryonic stem cells

We describe a screen for cellular response to drugs that makes use of haploid embryonic stem cells. We generated ten libraries of mutants with piggyBac gene trap transposon integrations, totalling approximately 100,000 mutant clones. Random barcode sequences were inserted into the transposon vector...

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Bibliografiska uppgifter
I publikationen:Sci Data
Huvudupphovsmän: Pettitt, Stephen J., Krastev, Dragomir B., Pemberton, Helen N., Fontebasso, Yari, Frankum, Jessica, Rehman, Farah L., Brough, Rachel, Song, Feifei, Bajrami, Ilirjana, Rafiq, Rumana, Wallberg, Fredrik, Kozarewa, Iwanka, Fenwick, Kerry, Armisen-Garrido, Javier, Swain, Amanda, Gulati, Aditi, Campbell, James, Ashworth, Alan, Lord, Christopher J.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group 2017
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Data Descriptor
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5332012/
https://ncbi.nlm.nih.gov/pubmed/28248920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sdata.2017.20
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