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Intravascular hemolysis and the pathophysiology of sickle cell disease

Hemolysis is a fundamental feature of sickle cell anemia that contributes to its pathophysiology and phenotypic variability. Decompartmentalized hemoglobin, arginase 1, asymmetric dimethylarginine, and adenine nucleotides are all products of hemolysis that promote vasomotor dysfunction, proliferativ...

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Bibliografiske detaljer
Udgivet i:J Clin Invest
Main Authors: Kato, Gregory J., Steinberg, Martin H., Gladwin, Mark T.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5330745/
https://ncbi.nlm.nih.gov/pubmed/28248201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI89741
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