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Vasculopathy in Sickle Cell Disease: Biology, Pathophysiology, Genetics, Translational Medicine and New Research Directions

Sickle cell disease has been very well characterized as a single amino acid molecular disorder of hemoglobin leading to its pathological polymerization, with resulting red cell rigidity that causes poor microvascular blood flow, with consequent tissue ischemia and infarction. More recently, an indep...

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Detalhes bibliográficos
Main Authors: Kato, Gregory J., Hebbel, Robert P., Steinberg, Martin H., Gladwin, Mark T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3209715/
https://ncbi.nlm.nih.gov/pubmed/19610078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ajh.21475
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