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Pathophysiology of Sickle Cell Disease

Since the discovery of sickle cell disease (SCD) in 1910, enormous strides have been made in the elucidation of the pathogenesis of its protean complications, which has inspired recent advances in targeted molecular therapies. In SCD, a single amino acid substitution in the β-globin chain leads to p...

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Detalhes bibliográficos
Publicado no:Annu Rev Pathol
Main Authors: Sundd, Prithu, Gladwin, Mark T., Novelli, Enrico M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7053558/
https://ncbi.nlm.nih.gov/pubmed/30332562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1146/annurev-pathmechdis-012418-012838
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