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Intravascular hemolysis and the pathophysiology of sickle cell disease

Hemolysis is a fundamental feature of sickle cell anemia that contributes to its pathophysiology and phenotypic variability. Decompartmentalized hemoglobin, arginase 1, asymmetric dimethylarginine, and adenine nucleotides are all products of hemolysis that promote vasomotor dysfunction, proliferativ...

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Foilsithe in:J Clin Invest
Main Authors: Kato, Gregory J., Steinberg, Martin H., Gladwin, Mark T.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Clinical Investigation 2017
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5330745/
https://ncbi.nlm.nih.gov/pubmed/28248201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI89741
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