Adipose tissue B2 cells promote insulin resistance through leukotriene LTB4/LTB4R1 signaling

Tissue inflammation is a key component of obesity-induced insulin resistance, with a variety of immune cell types accumulating in adipose tissue. Here, we have demonstrated increased numbers of B2 lymphocytes in obese adipose tissue and have shown that high-fat diet–induced (HFD-induced) insulin res...

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Bibliografische gegevens
Gepubliceerd in:J Clin Invest
Hoofdauteurs: Ying, Wei, Wollam, Joshua, Ofrecio, Jachelle M., Bandyopadhyay, Gautam, El Ouarrat, Dalila, Lee, Yun Sok, Oh, Da Young, Li, Pingping, Osborn, Olivia, Olefsky, Jerrold M.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Clinical Investigation 2017
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5330737/
https://ncbi.nlm.nih.gov/pubmed/28192375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI90350
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