SRC ONCOGENE INDUCES TROP2 PROTEOLYTIC ACTIVATION VIA CYCLIN D1

Proteomic analysis of castration-resistant prostate cancer demonstrated the enrichment of SRC tyrosine kinase activity in approximately ninety percent of patients. Src is known to induce cyclin D1, and a cyclin D1-regulated gene expression module predict poor outcome in human prostate cancer. The tu...

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Publicado en:Cancer Res
Main Authors: Ju, Xiaoming, Jiao, Xuanmao, Ertel, Adam, Casimiro, Mathew C., Di Sante, Gabriele, Deng, Shengqiong, Li, Zhiping, Di Rocco, Agnese, Zhan, Tingting, Hawkins, Adam, Stoyanova, Tanya, Ando, Sebastiano, Fatatis, Alessandro, Lisanti, Michael P., Gomella, Leonard G., Languino, Lucia R., Pestell, Richard G.
Formato: Artigo
Idioma:Inglês
Publicado: 2016
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5330252/
https://ncbi.nlm.nih.gov/pubmed/27634768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-3327
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