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Opportunities for Translation from the Bench: Therapeutic Intervention of the JAK/STAT Pathway in Neuroinflammatory Diseases

Pathogenic CD4(+) T cells and myeloid cells play critical roles in the pathogenesis of multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE), an animal model of MS. These immune cells secrete aberrantly high levels of pro-inflammatory cytokines that pathogenically bridge the in...

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Publicado en:Crit Rev Immunol
Autores principales: Liu, Yudong, Gibson, Sara A., Benveniste, Etty N., Qin, Hongwei
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5328657/
https://ncbi.nlm.nih.gov/pubmed/27279046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1615/CritRevImmunol.2016015517
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