Acquisition of an oncogenic fusion protein serves as an initial driving mutation by inducing aneuploidy and overriding proliferative defects

While many solid tumors are defined by the presence of a particular oncogene, the role that this oncogene plays in driving transformation through the acquisition of aneuploidy and overcoming growth arrest are often not known. Further, although aneuploidy is present in many solid tumors, it is not cl...

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Bibliografske podrobnosti
izdano v:Oncotarget
Main Authors: Loupe, Jacob M., Miller, Patrick J., Bonner, Benjamin P., Maggi, Elaine C., Vijayaraghavan, Jyothi, Zabaleta, Jovanny, Taylor, Christopher M., Tsien, Fern, Crabtree, Judy S., Hollenbach, Andrew D.
Format: Artigo
Jezik:Inglês
Izdano: Impact Journals LLC 2016
Teme:
Priority Research Paper
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5325330/
https://ncbi.nlm.nih.gov/pubmed/27588498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11716
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