Acquisition of an oncogenic fusion protein serves as an initial driving mutation by inducing aneuploidy and overriding proliferative defects

While many solid tumors are defined by the presence of a particular oncogene, the role that this oncogene plays in driving transformation through the acquisition of aneuploidy and overcoming growth arrest are often not known. Further, although aneuploidy is present in many solid tumors, it is not cl...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Loupe, Jacob M., Miller, Patrick J., Bonner, Benjamin P., Maggi, Elaine C., Vijayaraghavan, Jyothi, Zabaleta, Jovanny, Taylor, Christopher M., Tsien, Fern, Crabtree, Judy S., Hollenbach, Andrew D.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Priority Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5325330/
https://ncbi.nlm.nih.gov/pubmed/27588498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11716
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