SNAPIN is critical for lysosomal acidification and autophagosome maturation in macrophages

We previously observed that SNAPIN, which is an adaptor protein in the SNARE core complex, was highly expressed in rheumatoid arthritis synovial tissue macrophages, but its role in macrophages and autoimmunity is unknown. To identify SNAPIN's role in these cells, we employed siRNA to silence th...

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Bibliographische Detailangaben
Veröffentlicht in:Autophagy
Hauptverfasser: Shi, Bo, Huang, Qi-Quan, Birkett, Robert, Doyle, Renee, Dorfleutner, Andrea, Stehlik, Christian, He, Congcong, Pope, Richard M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis 2016
Schlagworte:
Basic Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5324844/
https://ncbi.nlm.nih.gov/pubmed/27929705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2016.1261238
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