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SNAPIN is critical for lysosomal acidification and autophagosome maturation in macrophages

We previously observed that SNAPIN, which is an adaptor protein in the SNARE core complex, was highly expressed in rheumatoid arthritis synovial tissue macrophages, but its role in macrophages and autoimmunity is unknown. To identify SNAPIN's role in these cells, we employed siRNA to silence th...

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Detalhes bibliográficos
Publicado no:Autophagy
Main Authors: Shi, Bo, Huang, Qi-Quan, Birkett, Robert, Doyle, Renee, Dorfleutner, Andrea, Stehlik, Christian, He, Congcong, Pope, Richard M.
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5324844/
https://ncbi.nlm.nih.gov/pubmed/27929705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2016.1261238
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