SNAPIN is critical for lysosomal acidification and autophagosome maturation in macrophages

We previously observed that SNAPIN, which is an adaptor protein in the SNARE core complex, was highly expressed in rheumatoid arthritis synovial tissue macrophages, but its role in macrophages and autoimmunity is unknown. To identify SNAPIN's role in these cells, we employed siRNA to silence th...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Autophagy
Main Authors: Shi, Bo, Huang, Qi-Quan, Birkett, Robert, Doyle, Renee, Dorfleutner, Andrea, Stehlik, Christian, He, Congcong, Pope, Richard M.
Format: Artigo
Jezik:Inglês
Izdano: Taylor & Francis 2016
Teme:
Basic Research Paper
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5324844/
https://ncbi.nlm.nih.gov/pubmed/27929705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2016.1261238
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