AMPK contributes to autophagosome maturation and lysosomal fusion

AMP-activated protein kinase (AMPK) regulates autophagy initiation when intracellular ATP level decreases. However, the role of AMPK during autophagosome maturation is not fully understood. Here, we report that AMPK contributes to efficient autophagosome maturation and lysosomal fusion. Using CRISPR...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Jang, Minsu, Park, Rackhyun, Kim, Hyunju, Namkoong, Sim, Jo, Daum, Huh, Yang Hoon, Jang, Ik-Soon, Lee, Jin I., Park, Junsoo
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6107659/
https://ncbi.nlm.nih.gov/pubmed/30140075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-30977-7
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