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Autophagy-receptors link myosin VI to autophagosomes to mediate Tom1-dependent autophagosome maturation and fusion with the lysosome
Autophagy targets pathogens, damaged organelles and protein aggregates for lysosomal degradation. These ubiquitinated cargoes are recognised by specific autophagy receptors, which recruit LC3-positive membranes to form autophagosomes. Subsequently, autophagosomes fuse with endosomes and lysosomes, t...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3472162/ https://ncbi.nlm.nih.gov/pubmed/23023224 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb2589 |
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