AMPK contributes to autophagosome maturation and lysosomal fusion

AMP-activated protein kinase (AMPK) regulates autophagy initiation when intracellular ATP level decreases. However, the role of AMPK during autophagosome maturation is not fully understood. Here, we report that AMPK contributes to efficient autophagosome maturation and lysosomal fusion. Using CRISPR...

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Publicat a:Sci Rep
Autors principals: Jang, Minsu, Park, Rackhyun, Kim, Hyunju, Namkoong, Sim, Jo, Daum, Huh, Yang Hoon, Jang, Ik-Soon, Lee, Jin I., Park, Junsoo
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6107659/
https://ncbi.nlm.nih.gov/pubmed/30140075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-30977-7
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