Inhibition of the mitochondrial calcium uniporter rescues dopaminergic neurons in pink1 (−/−) zebrafish

Mutations in PTEN‐induced putative kinase 1 (PINK1) are a cause of early onset Parkinson's disease (PD). Loss of PINK1 function causes dysregulation of mitochondrial calcium homeostasis, resulting in mitochondrial dysfunction and neuronal cell death. We report that both genetic and pharmacologi...

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Dettagli Bibliografici
Pubblicato in:Eur J Neurosci
Autori principali: Soman, Smijin, Keatinge, Marcus, Moein, Mahsa, Da Costa, Marc, Mortiboys, Heather, Skupin, Alexander, Sugunan, Sreedevi, Bazala, Michal, Kuznicki, Jacek, Bandmann, Oliver
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2016
Soggetti:
Molecular and Synaptic Mechanisms
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5324670/
https://ncbi.nlm.nih.gov/pubmed/27859782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/ejn.13473
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