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Restriction of mitochondrial calcium overload by mcu inactivation renders a neuroprotective effect in zebrafish models of Parkinson's disease

The loss of dopaminergic neurons (DA) is a pathological hallmark of sporadic and familial forms of Parkinson's disease (PD). We have previously shown that inhibiting mitochondrial calcium uniporter (mcu) using morpholinos can rescue DA neurons in the PTEN-induced putative kinase 1 (pink1)(−/−)...

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Detalhes bibliográficos
Publicado no:Biol Open
Main Authors: Soman, Smijin K., Bazała, Michal, Keatinge, Marcus, Bandmann, Oliver, Kuznicki, Jacek
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists Ltd 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6826286/
https://ncbi.nlm.nih.gov/pubmed/31548178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/bio.044347
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