Lanean...

Restriction of mitochondrial calcium overload by mcu inactivation renders a neuroprotective effect in zebrafish models of Parkinson's disease

The loss of dopaminergic neurons (DA) is a pathological hallmark of sporadic and familial forms of Parkinson's disease (PD). We have previously shown that inhibiting mitochondrial calcium uniporter (mcu) using morpholinos can rescue DA neurons in the PTEN-induced putative kinase 1 (pink1)(−/−)...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Biol Open
Egile Nagusiak: Soman, Smijin K., Bazała, Michal, Keatinge, Marcus, Bandmann, Oliver, Kuznicki, Jacek
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: The Company of Biologists Ltd 2019
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6826286/
https://ncbi.nlm.nih.gov/pubmed/31548178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/bio.044347
Etiketak: Etiketa erantsi
Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!