Inhibition of the mitochondrial calcium uniporter rescues dopaminergic neurons in pink1 (−/−) zebrafish

Mutations in PTEN‐induced putative kinase 1 (PINK1) are a cause of early onset Parkinson's disease (PD). Loss of PINK1 function causes dysregulation of mitochondrial calcium homeostasis, resulting in mitochondrial dysfunction and neuronal cell death. We report that both genetic and pharmacologi...

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Detalhes bibliográficos
Publicado no:Eur J Neurosci
Main Authors: Soman, Smijin, Keatinge, Marcus, Moein, Mahsa, Da Costa, Marc, Mortiboys, Heather, Skupin, Alexander, Sugunan, Sreedevi, Bazala, Michal, Kuznicki, Jacek, Bandmann, Oliver
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Molecular and Synaptic Mechanisms
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5324670/
https://ncbi.nlm.nih.gov/pubmed/27859782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/ejn.13473
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