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Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin

Mutations in Pink1, a gene encoding a Ser/Thr kinase with a mitochondrial-targeting signal, are associated with Parkinson’s disease (PD), the most common movement disorder characterized by selective loss of dopaminergic neurons. The mechanism by which loss of Pink1 leads to neurodegeneration is not...

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Detalhes bibliográficos
Main Authors: Yang, Yufeng, Gehrke, Stephan, Imai, Yuzuru, Huang, Zhinong, Ouyang, Yingshi, Wang, Ji-Wu, Yang, Lichuan, Beal, M. Flint, Vogel, Hannes, Lu, Bingwei
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2006
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1502310/
https://ncbi.nlm.nih.gov/pubmed/16818890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0602493103
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