Multiplex image-based autophagy RNAi screening identifies SMCR8 as ULK1 kinase activity and gene expression regulator

Autophagy is an intracellular recycling and degradation pathway that depends on membrane trafficking. Rab GTPases are central for autophagy but their regulation especially through the activity of Rab GEFs remains largely elusive. We employed a RNAi screen simultaneously monitoring different populati...

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Dades bibliogràfiques
Publicat a:eLife
Autors principals: Jung, Jennifer, Nayak, Arnab, Schaeffer, Véronique, Starzetz, Tatjana, Kirsch, Achim K, Müller, Stefan, Dikic, Ivan, Mittelbronn, Michel, Behrends, Christian
Format: Artigo
Idioma:Inglês
Publicat: eLife Sciences Publications, Ltd 2017
Matèries:
Biochemistry
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5323046/
https://ncbi.nlm.nih.gov/pubmed/28195531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.23063
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