Multiplex image-based autophagy RNAi screening identifies SMCR8 as ULK1 kinase activity and gene expression regulator

Autophagy is an intracellular recycling and degradation pathway that depends on membrane trafficking. Rab GTPases are central for autophagy but their regulation especially through the activity of Rab GEFs remains largely elusive. We employed a RNAi screen simultaneously monitoring different populati...

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Detaylı Bibliyografya
Yayımlandı:eLife
Asıl Yazarlar: Jung, Jennifer, Nayak, Arnab, Schaeffer, Véronique, Starzetz, Tatjana, Kirsch, Achim K, Müller, Stefan, Dikic, Ivan, Mittelbronn, Michel, Behrends, Christian
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: eLife Sciences Publications, Ltd 2017
Konular:
Biochemistry
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5323046/
https://ncbi.nlm.nih.gov/pubmed/28195531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.23063
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