Multiplex image-based autophagy RNAi screening identifies SMCR8 as ULK1 kinase activity and gene expression regulator

Autophagy is an intracellular recycling and degradation pathway that depends on membrane trafficking. Rab GTPases are central for autophagy but their regulation especially through the activity of Rab GEFs remains largely elusive. We employed a RNAi screen simultaneously monitoring different populati...

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Bibliografiske detaljer
Udgivet i:eLife
Main Authors: Jung, Jennifer, Nayak, Arnab, Schaeffer, Véronique, Starzetz, Tatjana, Kirsch, Achim K, Müller, Stefan, Dikic, Ivan, Mittelbronn, Michel, Behrends, Christian
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2017
Fag:
Biochemistry
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5323046/
https://ncbi.nlm.nih.gov/pubmed/28195531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.23063
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