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A C9ORF72/SMCR8-containing complex regulates ULK1 and plays a dual role in autophagy
The intronic GGGGCC hexanucleotide repeat expansion in chromosome 9 open reading frame 72 (C9ORF72) is a prevalent genetic abnormality identified in both frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). Smith-Magenis syndrome chromosomal region candidate gene 8 (SMCR8) is a pro...
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| Publicado no: | Sci Adv |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Association for the Advancement of Science
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5010369/ https://ncbi.nlm.nih.gov/pubmed/27617292 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.1601167 |
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