A C9ORF72/SMCR8-containing complex regulates ULK1 and plays a dual role in autophagy

The intronic GGGGCC hexanucleotide repeat expansion in chromosome 9 open reading frame 72 (C9ORF72) is a prevalent genetic abnormality identified in both frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). Smith-Magenis syndrome chromosomal region candidate gene 8 (SMCR8) is a pro...

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Vydáno v:Sci Adv
Hlavní autoři: Yang, Mei, Liang, Chen, Swaminathan, Kunchithapadam, Herrlinger, Stephanie, Lai, Fan, Shiekhattar, Ramin, Chen, Jian-Fu
Médium: Artigo
Jazyk:Inglês
Vydáno: American Association for the Advancement of Science 2016
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Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5010369/
https://ncbi.nlm.nih.gov/pubmed/27617292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.1601167
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