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Intrinsic Astrocyte Heterogeneity Influences Tumor Growth in Glioma Mouse Models

The influence of cellular origin on glioma pathogenesis remains elusive. We previously showed that mutations inactivating Rb and Pten and activating Kras transform astrocytes and induce tumorigenesis throughout the adult mouse brain. However, it remained unclear whether astrocyte subpopulations were...

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Detalhes bibliográficos
Publicado no:Brain Pathol
Main Authors: Irvin, David M., McNeill, Robert S., Bash, Ryan E., Miller, C. Ryan
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5322824/
https://ncbi.nlm.nih.gov/pubmed/26762242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bpa.12348
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