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Age-associated B cells express a diverse repertoire of V(H) and Vκ genes with somatic hypermutation
The origin and nature of age-associated B cells (ABCs) in mice is poorly understood. Here we show that their emergence required MHC class II and CD40/CD40L interactions. Young donor B cells were adoptively transferred into congenic recipients and allowed to remain for one month in the absence of ext...
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| 出版年: | J Immunol |
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| 主要な著者: | , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2017
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5322232/ https://ncbi.nlm.nih.gov/pubmed/28093524 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1601106 |
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