The V(H )gene repertoire of splenic B cells and somatic hypermutation in systemic lupus erythematosus
In systemic lupus erythematosus (SLE) it has been hypothesized that self-reactive B cells arise from virgin B cells that express low-affinity, nonpathogenic germline V genes that are cross-reactive for self and microbial antigens, which convert to high-affinity autoantibodies via somatic hypermutati...
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| Publicado no: | Arthritis Res Ther |
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| Principais autores: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BMC
2003
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC165037/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12718755/ https://ncbi.nlm.nih.govhttps://doi.org/10.1186/ar627 |
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