The V(H )gene repertoire of splenic B cells and somatic hypermutation in systemic lupus erythematosus

In systemic lupus erythematosus (SLE) it has been hypothesized that self-reactive B cells arise from virgin B cells that express low-affinity, nonpathogenic germline V genes that are cross-reactive for self and microbial antigens, which convert to high-affinity autoantibodies via somatic hypermutati...

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Publié dans:	Arthritis Res Ther
Auteurs principaux:	Fraser, Nicola LW, Rowley, Gary, Field, Max, Stott, David I
Format:	Artigo
Langue:	Inglês
Publié:	BMC 2003
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC165037/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12718755/ https://ncbi.nlm.nih.govhttps://doi.org/10.1186/ar627
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