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Resurrecting KIR2DP1 a Key Intermediate in the Evolution of Human Inhibitory NK cell Receptors that Recognize HLA-C

KIR2DP1 is an inactive member of the human lineage III KIR family, which includes all HLA-C specific receptors. The lethal, and only, defect in KIR2DP1 is a nucleotide deletion in codon 88. Fixed in modern humans, the deletion is also in archaic human genomes. KIR2DP1 is polymorphic, with dimorphism...

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Detalhes bibliográficos
Publicado no:J Immunol
Main Authors: Hilton, Hugo G., Blokhuis, Jeroen H., Guethlein, Lisbeth A., Norman, Paul J., Parham, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5321844/
https://ncbi.nlm.nih.gov/pubmed/28122963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1601835
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