Protein disulfide isomerase secretion following vascular injury initiates a regulatory pathway for thrombus formation

Protein disulfide isomerase (PDI), secreted by platelets and endothelial cells on vascular injury, is required for thrombus formation. Using PDI variants that form mixed disulfide complexes with their substrates, we identify by kinetic trapping multiple substrate proteins, including vitronectin. Pla...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Bowley, Sheryl R., Fang, Chao, Merrill-Skoloff, Glenn, Furie, Barbara C., Furie, Bruce
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5321760/
https://ncbi.nlm.nih.gov/pubmed/28218242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14151
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