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Protein disulfide isomerase secretion following vascular injury initiates a regulatory pathway for thrombus formation

Protein disulfide isomerase (PDI), secreted by platelets and endothelial cells on vascular injury, is required for thrombus formation. Using PDI variants that form mixed disulfide complexes with their substrates, we identify by kinetic trapping multiple substrate proteins, including vitronectin. Pla...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Bowley, Sheryl R., Fang, Chao, Merrill-Skoloff, Glenn, Furie, Barbara C., Furie, Bruce
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5321760/
https://ncbi.nlm.nih.gov/pubmed/28218242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14151
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