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hBfl-1/hNOXA Interaction Studies Provide New Insights on the Role of Bfl-1 in Cancer Cell Resistance and for the Design of Novel Anticancer Agents
[Image: see text] Upregulation of antiapoptotic Bcl-2 proteins in certain tumors confers cancer cell resistance to chemotherapy or radiations. Members of the antiapoptotic Bcl-2 proteins, including Bcl-2, Mcl-1, Bcl-xL, Bcl-w, and Bfl-1, inhibit apoptosis by selectively binding to conserved α-helica...
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| 出版年: | ACS Chem Biol |
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| 主要な著者: | , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Chemical
Society
2016
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| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5320539/ https://ncbi.nlm.nih.gov/pubmed/28026162 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.6b00962 |
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