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Intracellular drug bioavailability: a new predictor of system dependent drug disposition
Intracellular drug exposure is influenced by cell- and tissue-dependent expression of drug-transporting proteins and metabolizing enzymes. Here, we introduce the concept of intracellular bioavailability (F(ic)) as the fraction of extracellular drug available to bind intracellular targets, and we ass...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5320532/ https://ncbi.nlm.nih.gov/pubmed/28225057 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep43047 |
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