Identification of novel cancer therapeutic targets using a designed and pooled shRNA library screen

Targeted cancer therapeutics aim to exploit tumor-specific, genetic vulnerabilities specifically affecting neoplastic cells without similarly affecting normal cells. Here we performed sequencing-based screening of an shRNA library on a panel of cancer cells of different origins as well as normal cel...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Oliver, David, Ji, Hao, Liu, Piaomu, Gasparian, Alexander, Gardiner, Ellen, Lee, Samuel, Zenteno, Adrian, Perinskaya, Lillian O., Chen, Mengqian, Buckhaults, Phillip, Broude, Eugenia, Wyatt, Michael D., Valafar, Homayoun, Peña, Edsel, Shtutman, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5320502/
https://ncbi.nlm.nih.gov/pubmed/28223711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep43023
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