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Synthetic triterpenoid inhibition of human ghrelin O-acyltransferase: Involvement of a functionally required cysteine provides mechanistic insight into ghrelin acylation

The peptide hormone ghrelin plays a key role in regulating hunger and energy balance within the body. Ghrelin signaling presents a promising and unexploited target for development of small-molecule therapeutics to treat obesity, diabetes, and other health conditions. Inhibition of ghrelin O-acyltran...

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Publicat a:Biochemistry
Autors principals: McGovern-Gooch, Kayleigh R., Mahajani, Nivedita S., Garagozzo, Ariana, Schramm, Anthony J., Hannah, Lauren G., Sieburg, Michelle A., Chisholm, John D., Hougland, James L.
Format: Artigo
Idioma:Inglês
Publicat: 2017
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5319884/
https://ncbi.nlm.nih.gov/pubmed/28134508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.6b01008
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