Interferon-γ Limits Diabetogenic CD8(+) T-Cell Effector Responses in Type 1 Diabetes

Type 1 diabetes development in the NOD mouse model is widely reported to be dependent on high-level production by autoreactive CD4(+) and CD8(+) T cells of interferon-γ (IFN-γ), generally considered a proinflammatory cytokine. However, IFN-γ can also participate in tolerance-induction pathways, indi...

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Udgivet i:Diabetes
Main Authors: Driver, John P., Racine, Jeremy J., Ye, Cheng, Lamont, Deanna J., Newby, Brittney N., Leeth, Caroline M., Chapman, Harold D., Brusko, Todd M., Chen, Yi-Guang, Mathews, Clayton E., Serreze, David V.
Format: Artigo
Sprog:Inglês
Udgivet: American Diabetes Association 2017
Fag:
Immunology and Transplantation
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5319715/
https://ncbi.nlm.nih.gov/pubmed/27920091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db16-0846
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