Type 1 Interferons Potentiate Human CD8(+) T-Cell Cytotoxicity Through a STAT4- and Granzyme B–Dependent Pathway

Events defining the progression to human type 1 diabetes (T1D) have remained elusive owing to the complex interaction between genetics, the immune system, and the environment. Type 1 interferons (T1-IFN) are known to be a constituent of the autoinflammatory milieu within the pancreas of patients wit...

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Bibliographische Detailangaben
Veröffentlicht in:Diabetes
Hauptverfasser: Newby, Brittney N., Brusko, Todd M., Zou, Baiming, Atkinson, Mark A., Clare-Salzler, Michael, Mathews, Clayton E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Diabetes Association 2017
Schlagworte:
Immunology and Transplantation
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5697952/
https://ncbi.nlm.nih.gov/pubmed/28877912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db17-0106
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