mTOR and Neuronal Cell Cycle Re-entry: How Impaired Brain Insulin Signaling Promotes Alzheimer's Disease

A major obstacle to pre-symptomatic diagnosis and disease-modifying therapy for Alzheimer's disease (AD) is inadequate understanding of molecular mechanisms of AD pathogenesis. For example, impaired brain insulin signaling is an AD hallmark, but whether and how it might contribute to the synapt...

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Detalles Bibliográficos
Publicado en:Alzheimers Dement
Autores principales: Norambuena, Andrés, Wallrabe, Horst, McMahon, Lloyd, Silva, Antonia, Swanson, Eric, Khan, Shahzad S., Baerthlein, Daniel, Kodis, Erin, Oddo, Salvatore, Mandell, James W., Bloom, George S.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5318248/
https://ncbi.nlm.nih.gov/pubmed/27693185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jalz.2016.08.015
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