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Genetically reducing mTOR signaling rescues central insulin dysregulation in a mouse model of Alzheimer’s disease

Alzheimer’s disease (AD) is the most common neurodegenerative disease. The causes of sporadic AD, which represents more than 95% of AD cases, are unknown. Several AD risk factors have been identified and among these, type two diabetes increases the risk of developing AD by two-fold. However, the mec...

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Detalhes bibliográficos
Publicado no:Neurobiol Aging
Main Authors: Caccamo, Antonella, Belfiore, Ramona, Oddo, Salvatore
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6777740/
https://ncbi.nlm.nih.gov/pubmed/29729422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2018.03.032
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