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mTOR REGULATES TAU PHOSPHORYLATION AND DEGRADATION: IMPLICATIONS FOR ALZHEIMER’S DISEASE AND OTHER TAUOPATHIES

Accumulation of tau is a critical event in several neurodegenerative disorders, collectively known as tauopathies, which include Alzheimer’s disease and frontotemporal dementia. Pathological tau is hyperphosphorylated and aggregates to form neurofibrillary tangles. The molecular mechanisms leading t...

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מידע ביבליוגרפי
Main Authors: Caccamo, Antonella, Magrì, Andrea, Medina, David X., Wisely, Elena V., López-Aranda, Manuel F., Silva, Alcino J., Oddo, Salvatore
פורמט: Artigo
שפה:Inglês
יצא לאור: 2013
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3655115/
https://ncbi.nlm.nih.gov/pubmed/23425014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12057
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