Naturally Secreted Amyloid-β Increases Mammalian Target of Rapamycin (mTOR) Activity via a PRAS40-mediated Mechanism

Reducing the mammalian target of rapamycin (mTOR) activity increases lifespan and health span in a variety of organisms. Alterations in protein homeostasis and mTOR activity and signaling have been reported in several neurodegenerative disorders, including Alzheimer disease (AD); however, the causes...

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Hlavní autoři: Caccamo, Antonella, Maldonado, Monica A., Majumder, Smita, Medina, David X., Holbein, Walter, Magrí, Andrea, Oddo, Salvatore
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2011
Témata:
Molecular Bases of Disease
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3058958/
https://ncbi.nlm.nih.gov/pubmed/21266573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.180638
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