Dysregulation of the mTOR Pathway Mediates Impairment of Synaptic Plasticity in a Mouse Model of Alzheimer's Disease

BACKGROUND: The mammalian target of rapamycin (mTOR) is an evolutionarily conserved Ser/Thr protein kinase that plays a pivotal role in multiple fundamental biological processes, including synaptic plasticity. We explored the relationship between the mTOR pathway and β-amyloid (Aβ)-induced synaptic...

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Главные авторы: Ma, Tao, Hoeffer, Charles A., Capetillo-Zarate, Estibaliz, Yu, Fangmin, Wong, Helen, Lin, Michael T., Tampellini, Davide, Klann, Eric, Blitzer, Robert D., Gouras, Gunnar K.
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2010
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2942840/
https://ncbi.nlm.nih.gov/pubmed/20862226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0012845
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