Amyloid-β signals through tau to drive ectopic neuronal cell cycle re-entry in Alzheimer's disease

Normally post-mitotic neurons that aberrantly re-enter the cell cycle without dividing account for a substantial fraction of the neurons that die in Alzheimer's disease (AD). We now report that this ectopic cell cycle re-entry (CCR) requires soluble amyloid-β (Aβ) and tau, the respective buildi...

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Autores principales: Seward, Matthew E., Swanson, Eric, Norambuena, Andrés, Reimann, Anja, Cochran, J. Nicholas, Li, Rong, Roberson, Erik D., Bloom, George S.
Formato: Artigo
Lenguaje:Inglês
Publicado: The Company of Biologists 2013
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3635465/
https://ncbi.nlm.nih.gov/pubmed/23345405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.1125880
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