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Gliosis Precedes Amyloid-β Deposition and Pathological Tau Accumulation in the Neuronal Cell Cycle Re-Entry Mouse Model of Alzheimer’s Disease

BACKGROUND: The presence of cell cycle markers in postmortem Alzheimer’s disease (AD) brains suggest a potential role of cell cycle activation in AD. It was shown that cell cycle activation in postmitotic neurons in mice produces Aβ and tau pathologies from endogenous mouse proteins in the absence o...

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Detalhes bibliográficos
Publicado no:J Alzheimers Dis Rep
Main Authors: Park, Kevin H.J., Barrett, Tomás
Formato: Artigo
Idioma:Inglês
Publicado em: IOS Press 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7458550/
https://ncbi.nlm.nih.gov/pubmed/32904753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/ADR-200170
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